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After a comparison with the known IRAP structures and a combination with small angle X-ray scattering experiments it was proposed that IRAP is an open dimer in solution and assumes a more compact conformation upon HA08 binding
And on a side note we also have a much better understanding of why our metabolism slows down as we get older
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The peptide stimulates the synthesis of chondroitin sulfate and decorin, two essential components of the cartilage matrix
![PDF] Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans](https://figures.semanticscholar.org/563e37f40c2395525ecec5ca6cb5d79b0fb753dd/4-Table1-1.png)
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