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Important safety considerations include: Risk of acute pancreatitis: urgent medical review needed for severe, persistent abdominal pain (with or without back pain) Gallbladder disorders: seek medical advice for symptoms of gallstones (right upper abdominal pain, nausea) Diabetic retinopathy complications: particularly with semaglutide in those with pre-existing retinopathy Hypoglycaemia: risk is low unless combined with insulin or sulfonylureas, which may require dose adjustment Reports of mood changes and suicidal ideation in patients taking GLP-1 receptor agonists are being monitored by regulatory authorities
Reduced expression of mutant SOD1 in microglia delayed late disease progression and increased survival of SOD1 G37R mice (Boille et al., High calorie diets in ALS A number of studies have tried to correct the energy deficit using metabolic therapies in animal models and patients with ALS, with the hope that an improved metabolism can delay symptoms and extend survival in ALS (Dupuis et al., 2004
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