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Pro-inflammatory cytokines produced by adipose tissue support tumor-promoting intercellular crosstalk in the tumor microenvironment [14], thus enhancing tumor cell progression, angiogenesis, and invasion as essential requirements for metastasis [15]
21 Although the long-term retinal effects of GLP-1RA in DR arent fully understood at this time, an ongoing trial is investigating the extended effect of semaglutide on DR after 5 years of treatment
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