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After liraglutide treatment, cognitive scores were significantly correlated with changes in these activating brain regions ( P 30 kg/m 2 ) compared to placebo after 26 weeks of trial participation

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Quick Answer: GLP-1 receptor agonists may influence substance use behaviors through effects on brain reward circuits, but they currently have no FDA approval for treating substance use disorders

Understanding each drug's mechanism helps explain why combining them remains largely experimental and requires physician discretion