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This buildup of oxidative stress is one of the primary theories behind why melanocytes may become damaged
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Starting at the lower end (200-250mcg) allows tolerance assessment and side effect minimization before increasing to therapeutic doses, while taking doses higher than prescribed does not necessarily lead to additional benefit and may increase the risk of side effects due to physiologic feedback mechanisms
Animal Model and Ethics Statement Wistar rats from the breeding colony at the Universidade do Extremo Sul Catarinense (UNESC), Brazil, were housed four times per cage under controlled conditions of temperature (22 1 C), relative humidity (4555%) and light-dark cycle (12:12 p.m., light on at 6 a.m.)
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