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This acute response generates vast amounts of reactive oxygen species (ROS) designed to destroy the invading pathogens
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MSC skew the polarization of macrophages M2 expressing the anti-inflammatory mediators IL-1 and IL-4 and reduces the production of pro-inflammatory macrophages M1 expressing the inflammatory signals IL-12 and TNF- by secreting soluble molecules such as prostaglandin E2 (PGE2), TNF- stimulated gene/protein 6 (TSG-6), IL-6, G-CSF [103], and indolamine 2,3-dioxygenase (IDO) [104]
Khavinson V.K., et al
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