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These hostmicrobe interactions have been extensively reviewed, highlighting a bidirectional regulatory axis in which GLP-1 signaling and microbial metabolites coordinate energy balance and immunemetabolic processes

It has also been proposed that pyridoxine deficiency can have a role in the development of carpal tunnel syndrome, due to its critical role in peripheral nerve metabolism as a cofactor for neuronal protein synthesis (59)

Butyrate demonstrated beneficial effects on BMI and waist circumference in children, whereas vitamin B showed limited impact