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The study found that the effect of melatonin was not due to the melatonin receptors but rather acts in a receptor-independent manner to clear amyloid-beta plaque.[ref] In addition to clearing amyloid-beta plaque, another way that melatonin can protect against Alzheimers is through the reduction of ROS in the mitochondria in brain cells.[ref] This may be the key, rather than amyloid-beta clearance
I say more than because when I was looking at this data really in-depth back in, starting in 2012 to 2014, it was that and then it's now grown
R.NelsonJ
doi: 10.1038/s41580-020-00324-8 9 PietrangeloA
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