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It is investigated for its activity at central melanocortin receptors, particularly MC3R and MC4R, which are involved in neuroendocrine signaling
This is the mechanistic reason researchers study it separately from native IGF-1: with less protein-binding interference, the analog remains bioavailable roughly 3x longer, giving it an extended half-life of approximately 2030 hours compared to native IGF-1s 1215 hours
Monitoring cardiovascular effects Given the potential cardiovascular effects of retatrutide, close monitoring of heart rate and rhythm is recommended during treatment
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