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Fat loss accounts for roughly 60% of total weight loss after 12 weeks (Bolinder et al., Lancet Diabetes & Endocrinology 2014)

This includes variations between the type of GLP-1 agent, dose, duration of therapy or underlying patient phenotype such as body mass and metabolic rate, patients age, muscle activity, previous toxin treatments, and/or dosage

2009;297:F164755

Binding/competition metrics in receptor systems (e.g., IC50/Ki where applicable) Second-messenger readouts (assay-dependent) Pathway readouts (e.g., phosphorylation markers) in controlled cell models (assay-dependent) Receptor trafficking/internalization (imaging or tagged-receptor assays) Stability/integrity profiling (e.g., HPLC profiles