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If the notion of MS being a primary proteopathy is correct, this raises interesting and unexpected new therapeutic directions modeled on what is being developed for other neurodegenerative diseases such as Alzheimers
The primers used in this experiment are shown in Table S2
Immunity 43(1):6579 Zeissig S, Blumberg RS (2014) Life at the beginning: perturbation of the microbiota by antibiotics in early life and its role in health and disease
Additionally, it influences the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) and mitogen-activated protein kinase (MAPK) pathways, both of which play critical roles in cell survival and apoptosis regulation (217)
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