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SPARC (Secreted Protein Acidic and Rich in Cysteine) is a glycoprotein mainly expressed in embryonic tissues and tissues undergoing repair and remodeling
The mechanisms underlying these observations are not fully characterized
The elongation was sufficient to extend cellular proliferative capacity beyond the Hayflick limit the replicative ceiling normally imposed by critical telomere shortening
TB4 can upregulate VEGF via HIF-1 stabilization and engage pathways tied to cell survival and matrix remodeling
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