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In a trial called Surmount-1, researchers studied the once-weekly injectable in 2,500 adults without diabetes and found significant weight loss at 72 weeks

Individual results vary, but many people begin to notice a decrease in cravings and food noise within the first few weeks of adding naltrexone to their regimen

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Although recent meta-analysis of the SURPASS clinical trials did not detect an increase in risk of EWDR related to tirzepatide treatment [13], these studies did not implement additional retinal screening and their protocols excluded individuals with PDR, severe pre-proliferative retinopathy or maculopathy