Adlercreutz H, Pulkkinen MO, Hamalainen EK, et al
Sources Comparative review of semaglutide and tirzepatide mechanisms (Pharmacological Research, ScienceDirect) A Contemporary Rationale for Agonism of the GIP Receptor in the Treatment of Obesity (Diabetes, American Diabetes Association) GIP Receptor Agonism Attenuates GLP-1 Receptor Agonist-Induced Nausea and Emesis in Preclinical Models (PMC) Anorectic and aversive effects of GLP-1 receptor agonism mediated by brainstem CCK neurons, modulated by GIP (PMC) Head-to-Head Trial Compares Weight Loss Drugs (Weill Cornell Medicine Newsroom, reporting NEJM SURMOUNT-5) Head-to-head comparison of tirzepatide and semaglutide for weight loss: systematic review and meta-analysis (PubMed) Are You a GLP-1 Nonresponder
Additionally, berberine (and any supplement, for that matter) isnt subject to the same strict FDA regulations as prescription medication
lee82 December 14, 2023, 1:23pm 47 A friend of mine (a doctor & rec cyclist, that actually prescribes it) used it personally to help lose 60 pounds