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Taking semaglutide or tirzepatide without understanding what caused your metabolism to slow downwhether hormonal changes, thyroid dysfunction, or years of restrictive dietingmeans treating symptoms rather than root causes

In individuals with obesity, the brain's reward centres may respond more intensely to food cues, whilst satiety signals may become blunted

We talk about what the medication does and doesn't do : it reduces appetite signals, but it doesn't substitute for protein intake, sleep, or activity

Understanding the duration, the pauses, and the underlying mechanisms is what separates a well-designed study from a shot in the dark