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They are less effective against habitual eating, emotional eating, and food cue reactivity

Direct and Metabolite Effects: While direct GLP-1R expression on -cells is low, degradation products of GLP-1, such as GLP-1(9-36) , may also inhibit glucagon secretion by activating inhibitory G proteins (Gi/o) and modulating calcium channels (Zheng et al., 2024)

They also adjusted their analysis to account for differences in age and sex, helping to clarify whether certain groups might be more vulnerable