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Possible risks include: Rare but potentially serious reactions , including serotonin syndrome, particularly with certain antidepressants Increased side effects of antidepressants , as marijuana may raise medication levels in the body Fatigue, dizziness, diarrhea, cough, or nausea Increased anxiety or panic attacks , which has been reported in limited case studies Cognitive changes , such as impaired attention, confusion, or slowed thinking Mood changes , including irritability or emotional blunting Worsening depressive symptoms in some individuals, even if marijuana initially seems to help For individuals using cannabis to manage chronic pain, combining marijuana with antidepressants may increase the likelihood of side effects, as both can affect the central nervous system and overall alertness

Deepak, A., Goyal, A

So if someone is low in B12 and they consume alcohol, they not only don't have enough B12 to help 'clear away' the alcohol toxins but they also risk increasing homocysteine levels which I believe is that feeling of heat/hangover that can persist when there isn't enough B12 to reset the body