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This site-specific modification requires additional synthetic steps, purification, and analytical characterization to ensure correct attachment and final product quality
Most treatment discontinuations were due to gastrointestinal AE and occurred during the rapid escalation phase this may be mitigated with more gradual dose escalation at phase 3 trials
The increase of glutamate neurotransmission is associated with epileptic crisis (Devinsky, et al
Avoid eyes and sensitive areas
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