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B-complex vitamins serve as coenzymes or precursors in numerous biochemical reactions, and together they work synergistically to support metabolism, neurological function, and cellular energy production

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122,123 It has been well identified that parathyroid hormone-related protein (PTHrP) acts in conjunction with Indian hedgehog to inhibit chondrocyte hypertrophy and regulates endochondral ossification through a negative-feedback loop

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