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Semaglutide is also the first (and so far only) GLP-1 receptor agonist shown to decrease the risk of heart attacks and strokes among people who dont have diabetes, so thats a game changer in the landscape of obesity medicine, Pedersen says

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Excessive Vitamin B12 May Increase the Risk of Lung and Colon Cancer A large-scale 2017 study published in the Journal of Clinical Oncology found that males who supplemented with megadoses of vitamins B6 and B12 had a 30% to 40% increased risk of lung cancer compared to individuals who did not supplement

Individuals who used GLP-1RAs for 0.5, 1, and 1.5 years had IRRs close to 1.0, with no significant decrease in MACE risk at three years, although these estimates varied across specific treatment strategies defined by prior duration and subsequent exposure patterns