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Increased irritability : Getting frustrated or upset more easily than usual Emotionally flat: Being emotionally numb, like going through the motions without feeling much Lower energy or motivation: Feeling less enthusiastic about things they usually love Anxiety: A heightened sense of worry or nervousness Difficulty focusing: Finding it harder to concentrate or think clearly How can GLP-1 drugs affect mental health

Glutamine-derived aspartate induced by GOT2 is transported into the cytosol and converted by GOT1 to oxaloacetate, then converted by malate dehydrogenase (MDH1) into malate and subsequently oxidized into pyruvate by ME1 to create NADPH

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Weight-loss medications: Current evidence and recommendations