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The critical role of NAD + pool in tumorigenesis NAD + not only acts as a co-enzyme for metabolic redox reactions, but also functions as a co-substrate to modulate the activity of NAD + -consuming enzymes that govern the critical steps in tumorigenesis, including genome stability, metabolism, cell growth, cell death, redox homeostasis and immune response
The two factors could add up to a loss of strength and function
more damage to genes
This chronic inflammatory state further exacerbates neuronal damage and death, creating a vicious cycle
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