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SODs of Class I specifically require manganese or iron ion for catalytic activity (MnSOD and FeSOD) and enzymes that function with either of the two metal ions socalled cambialistic SODs
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The reduction of specific amino acids, such as glycine, serine, and proline, in the early stage may lead to an imbalance in macrophage polarization, thereby enhancing inflammatory responses in CIA mice (87)
& Wen, J
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