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Importantly, the frequency of these side effects declined as participants settled into their maintenance dosage, suggesting that adaptation occurred with ongoing weekly dosing

To test this idea, Mojsov and Habener collaborated with Gordon Weir, showing that miniscule quantities of this peptide dramatically increased insulin secretion by the rat pancreas

The large concentration difference between GSH and GSSG creates a dynamic-range challenge, requiring calibration and dilution procedures that maintain GSSG sensitivity without GSH saturation or carryover