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In general, it appears creatine supplementation may improve some aspects of cognitive function, particularly short-term memory and reasoning, and its effects appear to be more pronounced in stressful conditions such as low oxygen levels, sleep deprivation, or complex and demanding cognitive tasks
De Groot, L
While its often found as part of a B-complex supplement (B vitamins), B12 stands out for its unique benefits
Naltrexone complements this process by blocking feedback signals that would normally limit that activity
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