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Patients should reach out if they experience persistent nausea, vomiting, or diarrhea that prevents adequate nutrition or hydration (which may lead to dehydration and kidney problems)

The nasal delivery route offers some unique advantages

This multicenter, double-blind, placebo-controlled Phase 2 RCT (NCT05377580) enrolled 150 Chinese patients who were randomized to receive various doses of Picankibart through intravenous injection during the induction period (Period 1) followed by subcutaneous maintenance therapy (Period 2), with quadruple masking involving participants, care providers, investigators, and outcomes assessors

That said, some patients may need to stop due to: In all of these cases, a transition plan should be in place before stopping not developed reactively after weight regain begins