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In a 2-year trial involving patients with type 2 diabetes mellitus (T2DM) and high cardiovascular risk, more events of diabetic retinopathy complications occurred in patients treated with semaglutide 0.5 and 1 mg once weekly injections (3%) compared to placebo (1.8%)

The trade-off is the fixed 5:1 ratio: you cannot raise one compound without raising the other

Gradual dose titration remains one of the most effective approaches

94 Although the mechanistic basis remains less well defined than in the kidney, these findings suggest that highly organized tissue architecture may impose directional constraints on ferroptotic spread, effectively channeling the trajectory of injury through anatomical structure