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Evidence-based alternatives include structured nutrition with adequate protein intake, progressive resistance training, appropriate cardiovascular exercise, and consultation with sports medicine professionals and registered dietitians

it addresses both the cellular trigger (oxidative stress in the mast cell) and the systemic clearance mechanism (hepatic detoxification)

The confirmed harms were a small increase in liver enzymes, a roughly 1% incidence of muscle symptoms, and a modest rise in blood sugar in patients already near the diabetes threshold

Retatrutide represents a promising pipeline compound that could expand the therapeutic toolkit, especially for patients with concurrent MASLD/MASH where glucagon-mediated hepatic fat oxidation may provide additional benefit