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Quite remarkably, in those with low POP levels, the typically robust association between diabetes and obesity was not observed in a nested case-controlled study, suggesting that obesity may exaggerate the metabolic disturbances caused by POPs (perhaps because adipose tissue provides a reservoir for fat-soluble toxins), rather than being directly responsible for the altered metabolism

(PubMed) Harbige LS

The primary endpoint, a composite of MACE (CV death, nonfatal myocardial infarction (MI), or nonfatal stroke), occurred in 3.8% of the semaglutide group and 4.8% of the placebo group

However, insulin elevation from food intake activates opposing lipogenic (fat-storing) pathways that can blunt the peptides fat-mobilizing effects