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Finally, we evaluate how approaching these pathologies from a network level is a necessary direction for translational future research
The variable weight value (VIP) in Orthogonal Partial Least Squares-Discriminant Analysis is a measure of the expression pattern of each metabolite, the explanatory ability and depth of influence on the categorical discrimination of samples in each group, to explore meaningful differential metabolites, and then use the T-test to verify whether the differential metabolites between groups are significant
Increased HIF-1 activity stimulates ASCT2 transcription alongside other amino acid transporters to boost glutamine uptake which supports cell survival and proliferation within hypoxic tumor settings
The restoration of GSH involves the action of the NADPH-dependent enzyme, glutathione reductase
