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doi:10.14309/ajg.0000000000000573 Longstreth GF, Wong C, Chen Q

For local injection site reactions potentially related to antibodies: Rotate injection sites systematically among recommended areas (abdomen, thigh, upper arm) Apply cold compresses before injection and warm compresses afterward if tolerated Consult with your healthcare provider before using any topical treatments, including corticosteroids, which should only be used short-term if recommended Ensure proper injection technique and medication storage Monitor for progression or systemic symptoms Mild local reactions that do not worsen over time may be managed conservatively with continued treatment and observation