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A Caco-2 bidirectional transport assay showed an apparent permeability (P app ) of 34.2 10 6 cm/s from apical to basolateral and 45.2 10 6 cm/s from basolateral to apical, with an efflux ratio of 1.33, indicating high permeability and no significant efflux
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Key Preclinical Study (Neelakantan et al., 2018): Treatment in diet-induced obese mice produced progressive body weight loss, reduced white adipose tissue mass and adipocyte size, decreased total cholesterol, and no changes in food intake effects were metabolic, not appetite-driven
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