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Oral replacement can be difficult during periods of vomiting and IV replacement is frequently necessary

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Pairing glutathione with vitamin C amplifies its effectiveness, as vitamin C helps recycle glutathione back into its active form

Weight regain of 1% from discontinuation was significantly associated with increased hazards of reinitiation of 2.3% (95% CI, 1.9%-2.8%) for patients with type 2 diabetes and 2.8% (95% CI, 2.4%-3.2%) for patients without type 2 diabetes