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Temperature excursions, contaminated bacteriostatic water, and improper sterile technique accounted for the majority of degradation events, meaning researchers were unknowingly working with compromised compounds from day one

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The honest answer is that the human safety data is limited compared to decades-old pharmaceuticals, but the preclinical safety record across multiple species is unusually clean for a peptide with this level of biological activity

Azelaprag for obesity: Genetic evidence supports the potential of azelaprag to improve metabolism Consistent with the metabolic benefits of azelaprag observed in our Phase 1b clinical trial, genetic studies of apelin in mice published by other groups provide support for the potential role of azelaprag in the treatment of obesity