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Los investigadores incorporaron las asociaciones genticas a un modelo ms amplio que tambin incluye factores demogrficos y clnicos, demostrando la capacidad de estratificar a los individuos segn la eficacia esperada en la prdida de peso y el riesgo de ciertos efectos secundarios
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J Clin Invest 117:21552163 Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K (2009) Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function
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