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As a result, NASH and fibrosis need to be evaluated independently to ensure a beneficial impact on one parameter does not simultaneously result in a negative impact on another endpoint of interest, particularly given that individual treatments tend to focus on one primary mechanism of action (i.e

Immune-mediated responses The immune system can develop antibodies against GLP-1 receptor agonists, particularly those based on non-human peptide sequences

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Oxidative stress occurs when there's an imbalance between free radicals (unstable molecules that damage cells) and antioxidants (the molecules that neutralize them)