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Which drains glutathione further
Importantly, 5FU-based combination treatment also shows an increase in mitochondrial mass (FOLFOX (5FU + 1 M oxaliplatin) or FOLFIRI (5FU + 5 nM SN38, active metabolite of irinotecan)) that we attribute to 5FU-imposed stress, given that single-agent oxaliplatin or SN38 do not promote the same degree of mitochondrial adaptation (Extended Data Fig
JACCP JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY
Both compounds delay gastric emptying through different pathways, and the additive effect can produce nausea severe enough to derail otherwise compliant patients
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