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Thus, it is expected that hypoalbuminemia will not, to any relevant extent, reduce the albumin-bound fraction of semaglutide further and will therefore also have negligible influence on the semaglutide pharmacokinetic profile after IcoSema administration
Their impact on blood sugar levels can be unpredictable
But the magnitude of natural GLP-1 release is far smaller and shorter-lasting than what prescription agonists achieve
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