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In both HepG2 cells (experimental data) and PHHs (data from TG-GATES), NFT revealed an activation of module 144, showing oxidative stress response as the module ontology (Fig

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Stress-responsive transcription factors Stress-responsive transcription factors, including p53, nuclear factor erythroid 2related factor 2 (Nrf2), FOXOs, activating transcription factors ( ATFs), and hypoxia-inducible factor-1 (HIF-1), mediate cellular responses to diverse stressors, such as DNA damage, oxidative stress, hypoxia, ER stress, and metabolic imbalance

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