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Effects of prolonged exposure to low dose metformin in thyroid cancer cell lines
Mean increases in resting heart rate have been observed in randomized clinical trials of semaglutide and are documented in FDA prescribing information
Data from the STEP and SUSTAIN clinical trial programmes have shown that weight loss with semaglutide includes some reduction in lean body mass alongside fat mass, which could potentially contribute to muscle symptoms
For a deeper look at how these medications work, see our guide on what GLP-1 does in the body
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