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It's a catastrophic, yet entirely avoidable, failure
Our data above indicated that GSH deficiency upregulated mTORC1 signaling in mutant FoB
Astrocytes with low GSH may become less protective over time, releasing more inflammatory mediators and failing to supply an adequate amount of GSH and GSH precursors to neighboring neurons and microglia (Kwon et al., 2019
We are thankful to Margarethe Schimpf and Viktoria Liman for technical support and to the Med3 team of study ambulance in Erlangen for access to human samples
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