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There, it binds to specific receptors, signaling the gland to release more of its own growth hormone
ATIs are resistant to heat and digestive enzymes, and upon ingestion, they can activate the TLR4MD2CD14 complex, leading to the infiltration of intestinal macrophages and dendritic cells and the release of mediators like TNF- and IL-1, which induces an inflammatory response that is most pronounced in the colon and decreases progressively through the ileum to the duodenum (177)
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