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Innovative approaches, such as triphenylphosphonium derivative (TPT) nanoparticles, hyaluronic acid-coated particles, and polymeric nanovehicles, show promise in improving nanoparticle circulation time and tumor accumulation, enhancing therapeutic efficacy [334, 439,440,441,442,443]
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ROS can induce damage to both nuclear and mitochondrial DNA through multiple mechanisms and also damage the integrity of mitochondrial permeability transition pore (mPTP), thereby aggravating the dysregulation of mitochondrial dynamics and the control of apoptosis (5052)
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