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(2026): Glucagon-like peptide 1-based therapies for the treatment of type 2 diabetes mellitus
This glucose-lowering agent is secreted by intestinal enteroendocrine L-cells in response to nutritional and inflammatory stimuli and by neurons in the nucleus of the solitary tract in the brainstem
Recognition of this has spurred a number of innovative approaches that, despite their preclinical promise, have yielded disappointing efforts at translation into a meaningful clinical role
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