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Available evidence suggests a role for voltage-dependent anion channel (VDAC), located in the OMM, and adenine nucleotide translocase (ANT) across the IMM ( 2 + -induced swelling and MPT, although at a higher threshold, which has been interpreted as evidence against a role for ANT in MPT (Sileikyte et al., 2014)

See the AAAaAI review, a related PubMed case series and an FDA pharmacovigilance memo for more detail

One of which was discussed earlier, on NAD + /NMN levels regulating axon degeneration through SARM1

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