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However, inhibition of PHGDH, when combined with carboplatin treatment, significantly reduced Ki67+ cells and increased CC3+ apoptotic cells

Apart from that, the activation of Nrf2 by chlorogenic acid restores mitochondrial ion protein homologue (Lon) protein expression and reduces mitochondrial HSP60 release, attenuating APAP-induced inflammatory liver injury ( Caffeic acid is a common phenolic chemical found in a wide variety of plants

For example, a mouse model showed a 45% drop in the GSH/GSSG (glutathione disulfide) ratio after just one week of urban air exposure, alongside increased markers of oxidative stress like lipid peroxidation and protein carbonyls

J Clin Endocrinol Metab 92(4):12631268