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PT-141 was safely administered and well tolerated in both studies
Bottom Line Constipation is a common and manageable side effect of GLP-1 therapy
Research shows it modulates immune responses in the gut, strengthens intestinal barrier function, and influences the signaling environment around enteroendocrine cells, which include the L-cells that produce GLP-1
Both carry potential side effects, and for women, the risks extend beyond skin deep into hormonal balance, cardiovascular health, and long-term safety
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