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Deficiencies in thyroid, gonadal, adrenal or growth hormone axes are addressed according to the pattern

Weeks 12: 2 mg once weekly Weeks 36: 4 mg once weekly Weeks 710: 8 mg once weekly Week 11+: 12 mg once weekly (if tolerated) Fast escalation: Select cases, monitored closely This fast-escalation schedule is used only in specific situations where close supervision is available, such as in specialty clinics or structured clinical trial settings that follow strict safety protocols

Furthermore, in ALS, microglia appear to increase in cell size and granularity [30]

Avoid the eyelids, corners of the nose, and broken or irritated skin