is retatrutide a triple agonist vs Tirzepatide: Which Weight-Loss Drug Better? First Retatrutide phase 3 data,

Abbreviations PsA: Psoriatic arthritis PsO: Psoriasis RA: Rheumatoid arthritis HC: Healthy control CASPAR: ClASsification for psoriatic ARthritis DAPSA: Disease activity PsA PCA: Principal component analysis OPLS-DA: Orthogonal partial least squares discriminant analysis VIP: Variable influence on projection ROC: Receiver operator characteristic curves AUC: Area under the curve DT2: Diabetes type 2 BCAAs: Branched-chain amino acids CRP: C-reactive protein GSH: Glutathione Trp: Tryptophan References Ritchlin, C

doi: 10.1101/gad.177857.111 235 CoskunTBinaHASchneiderMADunbarJDHuCCChenYet al

C.KanoskiS

Recent studies have also demonstrated that exendin-4 is mediated by Ca 2+ /calmodulin (CaM)-dependent protein kinase kinase/CAM-dependent protein kinase IV/prolactin regulatory element binding (CaMKK/CaMKIV/PREB) pathway increases liver ABCA1 expression and reduces cholesterol accumulation [71]