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The requirement of two distinct glutathione interaction sites for the efficient reduction of GSSR by GSH explains the deviating properties and substrate preferences of glutaredoxin subfamilies as well as thioredoxins with implications for the design and optimization of artificial enzymes and inhibitors

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Supplementing with both vitamins can help mitigate these risks, especially during winter months when sunlight exposure is limited, and Vitamin D production in the body is lower